The Complement System and Antibody-Mediated Transplant Rejection
نویسندگان
چکیده
منابع مشابه
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Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndro...
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Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and insidious alloantibody-mediated graft injury. Half of heart transplant recipients develop chronic rejection within 10 years - a daunting statistic, particularly for young pati...
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The complement system plays multiple pathogenetic roles in rejection of renal allografts and one of the components, C4d, is an important diagnostic marker of antibody mediated rejection (1, 2). Complement proteins (e.g., C3) arose as an ancient, innate defense system in invertebrates that preceded the adaptive immune system in phylogeny. It is not surprising that during evolution these compleme...
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Advances in immunosuppression have decreased the incidence of acute rejection, but the development of vasculopathy in the coronary arteries of transplants continues to limit the survival of cardiac allografts. Transplant vasculopathy has also been referred to as accelerated graft arteriosclerosis because it has features of arteriosclerosis, but it is limited to the graft and develops over a per...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2015
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1501686